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RESEARCH & SCIENCE

A new map of the living
autonomic nervous system.

Autonomic science has been constructed on neuroanatomical maps derived primarily from cadaver dissection that cannot map the fine fiber networks that constitute the living dynamism of the afferent ANS. The autonomic nervous system — observed in vivo, in real clinical encounters, across thousands of cases — behaves quite differently than those maps predict.

The Autonomics research program begins with the gap between observed clinical phenomena and the neural and neurochemical cartography that purports to undergird it. It documents what the living system actually does, elaborates a refined three variable autonomic context-sensing, neurological, and neurochemical framework that accounts for those observations, and builds the diagnostic and taxonomic infrastructure a new clinical science requires.

12 preprints

published on Researchgate.

6 papers in production

extending the foundation model and its implications.

5000 people informing the foundation model

from 50 countries around the world.

100+ advisors

spanning 25 disciplines in the healing arts– from neurophysiology to developmental biology to connection science to deep ecology to mindful awareness to Indigenous Lifeways to data science – and 24 cultures, many of them Indigenous.

The work is published as preprints while peer-reviewed submission proceeds.

PUBLISHED RESEARCH

Building the field from the ground up.

Twelve published preprints. A systematic research program that begins with the foundational map of the living autonomic nervous system and extends through its diagnostic methodology, its neuroanatomy and neurochemistry, its re-interpretation of disease etiology, and its implications for clinical praxis.

FIELD POSITIONING

October 2026- Field Positioning

Breaking the Stasis in the Polyvagal Controversy: Two Category Errors, a Missing Variable, and a Measured Boundary

with Heather MacDuffie, PhD

Polyvagal theory has shaped a generation of clinical practice. Grossman et al.’s 2026 critique with 38 experts in vagal physiology has dramatically challenged its status. Yet neither party articulates the variable that would permit adjudication of the debate in living subjects. The paper proposes that variable - neurochemical context - as the thing that makes the predictions of PVT testable. It restores the sensory side of the autonomic nervous system to its rightful place, places the differentiated vagus on direct measurement, changes the explanatory scaffold for the passage between danger and lifethreat states, and clarifies that APPEASING, PLACATING, INTIMACY/UNION, PLAY, and TONIC IMMOBILITY are not simply or primarily autonomic states comprised of multiple neural systems (hybrid-states in PVT) but the visible edge of an entire dimension missing from PVT.

April 2026- Field Positioning

Moving Past the Polyvagal Controversy: An Expanded Clinical Framework for Observing Autonomic State

with Heather MacDuffie, PhD

Polyvagal theory has shaped a generation of clinical practice. This paper addresses the controversy directly and introduces the Autonomics framework as an expanded model that supersedes the debate.

FOUNDATION

June 2026- Epistemology & History of Science

Forest Not Lumberyard: Methodological Bias, Structural Error, and a Necessary Transformation of the Epistemic Ground of Autonomic Neuroanatomy

The most foundational argument in the program. Identifies four compounding sources of structural error in the field's neuroanatomical maps and makes the case for building from different epistemic ground.

September 2025- Autonomic Neuroanatomy

Towards an Accurate In Vivo Reconceptualizing of Autonomic State

The foundational paper. Introduces the three-system model, the three-variable construction of autonomic state, and the clinical validation dataset. This is the foundation map the subsequent papers extend.

July 2026- Autonomic Neuroanatomy

The Perinatal Autonomic Cascade: A Sequential Model of Neonatal Autonomic Initiation

The Perinatal Autonomic Cascade is a precisely ordered sequence of neurological initialization events that completes once after birth and establishes the foundational parameters of the organism's autonomic architecture for terrestrial life.

July 2026- Autonomic Neuroanatomy

There is No Such Thing as a Primitive Reflex: Restructuring Reflexes as a Distinct Category of Hardwired Autonomic Calibration

What developmental neuroscience calls ‘primitive reflexes’ are the visible motor output signatures of a sequential series of foundational autonomic initialization events. The paper introduces the term restructuring reflex as the correct functional category.

September 2025- Autonomic Neuroanatomy

Autonomics Poster — Foundation Model

Visual representation of the foundation model. For those who prefer to see the architecture before reading the argument.

CLINICAL IMPLICATIONS

October 2025- Clinical

A Typology of Chronic Defensive Autonomic States as Specific Antecedents to Disease Etiology

Approximately 80% of primary care presentations are stress-related. This paper provides what has been missing: a specific taxonomy linking chronic autonomic states to disease categories, and a corresponding framework for more targeted intervention.

DIAGNOSTICS

October 2025- Autonomic Diagnostics

Autonomic Diagnostics: Towards Accurate In Vivo Autonomic Measurement

HRV has become the de facto standard for autonomic measurement. This paper identifies its structural limitations and proposes a more accurate alternative grounded in direct in vivo observation.

METHODOLOGY

March 2026- Methodology

Autonomic Tracking: Methodological Viability of an Alternative Epistemological Approach

The epistemological argument for hard-ground tracking as a valid mode of in vivo autonomic observation — and a methodological defense of the approach underlying this research program.

THE FOUNDATION

Built from primary observation.

The Autonomics model was not derived from existing literature. It was built from direct clinical observation, cross-cultural validation, and a crowdsourced dataset assembled specifically to avoid the sampling biases that have shaped Western autonomic science.

This is not a revision of existing theory. Part of our research program is ground-clearing work the field has deferred. The Autonomics framework identifies four compounding sources of structural error in foundational autonomic neuroanatomy — and builds from entirely different epistemic ground. It traces how a long-standing brain-centric bias has fundamentally misconfigured the field’s understanding of human neurology. These are not minor corrections. Removing that bias transforms what the living system is understood to be and how it is understood to function. This critical work explains why prior models are inaccurate. It is the necessary precondition for everything that follows.

Our primary research objectives are aimed further forward, at advancing human flourishing. The program investigates how autonomic state is constructed in vivo; the functional and physiological coordination of the inward senses — interoception, proprioception, and the vestibular sense — and their integration with the autonomic systems; embryonic and perinatal autonomic neurodevelopment and how the human organism establishes functional autonomic baselines; what optimal neurodevelopment looks like and how disruptions to it propagate across a lifespan; the pattern language of salutogenic and pathogenic states and how they undergird both wellbeing and disease etiology; and how to intervene successfully in autonomic and physiological conditions — including those that have been misclassified as psychological in origin.

Peer-reviewed submission is in progress.

Built from primary observation.

Visiting the Palazzo dell'Archiginnasio e Teatro Anatomico at the University of Bologna as part of the research for our Forest not Lumberyard paper.

GO DEEPER WITH US

LECTURE SERIES ⌖ MONTHLY SESSIONS THROUGH MARCH 2027

Architecture & Dynamics of the Living Autonomic Nervous System

RESERVE A SEAT →

A deep dive into the intellectual history of autonomic science, this lecture series reaches back to the origins of the field nearly 2,000 years ago in ancient Rome, exploring how category errors in its foundations have infiltrated the modern view of the nervous system. Asks the big questions – why do you have a nervous system? What is stress? What is wellbeing? Redraws the neuro-anatomical maps of your autonomic nervous system from first principles. Modifies how we understand the ways that they coordinate and de-coordinate. Breaks the stasis in the Polyvagal Controversy.

Yearlong Autonomics Practicum

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Our deepest yearlong training in the art & science of Autonomics. The deepest dive into our pedagogical model: neural cartography, transformation of the ANS, autonomic tracking. For practitioners interested in centralizing the living nervous system in their practice.

Retreats & Residential Trainings

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From trainings at our headquarters Northern California (45 minutes NW of San Francisco), to Omega Institute for Holistic Studies (Gabriel is faculty), to trainings at our new hosting venue in Northwest Italy (fly into Milan).

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